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Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire.
2017-07-13
Ryan Emerson and colleagues report immunosequencing of the variable region of the TCR[beta] chain in 666 individuals with known cytomegalovirus (CMV) status. They show that CMV status and HLA genotype shape the T cell repertoire and demonstrate proof of principle that TCR[beta] sequencing can be used as a specific diagnostic of pathogen exposure.
